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Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility
Manal A Tawfeek, Manal A Eid, Azza M Hasan, Manal Mostafa, Hesham A El-Serogy
BMC Women's Health , 2012, DOI: 10.1186/1472-6874-12-10
Abstract: The study was conducted on 25 infertile women with unexplained infertility for at least two years and 10 normal fertile women as a control group . Endometrial tissue and uterine flushing were obtained. Each tissue specimen was divided into two pieces; one piece was used for histological dating of the endometrium and for immunostaining of progesterone receptors, and the second was used for RNA extraction and PCR assay of LIF and gp130 mRNA expression. Serum estrogen and progesterone were measured for all subjects. LIF mRNA was expressed in the endometrium of all normal fertile women but significantly decreased in infertile women. LIF was not detectable in 88% of infertile women while it was fairly detectable in 12% of them. Gp130 mRNA was hardly detectable in both fertile and infertile women with no difference between them. Infertile women secreted significantly less LIF and gp130 molecules in the uterine flushing compared with normal fertile women.Expression of LIF mRNA in endometrium could be used as a molecular marker of unexplained infertility. Assessment of secreted LIF and gp130 molecules in uterine flushing could be another useful and safe method for predicting successful implantation as well as for diagnosing and eventually treating women with impaired fertility using recombinant human LIF.One in ten couples has problems conceiving. Of these, 25% have unexplained infertility [1]. Embryo implantation is a critical step in establishment of pregnancy. Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium (decidua). In humans, the process of implantation can be divided into three phases: apposition, adhesion, and invasion. The opposition comprises the blastocyst orientation in the uterine cavity towards the endometrium. During the adhesive and invasive phases, the blastocyst approaches the epithelium, attaches itself to it, and the embryo trophoblast invades the deciduas. All these steps are controlled by a
The Relationship between Circulating Levels of Osteopontin with Carotid Intima-Media Thickness in Children on Regular Hemodialysis  [PDF]
Raghda Mohamed, Enas Tawfeek, Manal Abdel-Salam, Niveen Mohamed Ghoraba, Hala Maghraby
Open Journal of Nephrology (OJNeph) , 2021, DOI: 10.4236/ojneph.2021.114039
Abstract: Background: Chronic kidney disease (CKD) is associated with cardiovascular morbidity and mortality. Osteopontin (OPN) is a critical factor in developing atherosclerosis and increases the risk for a major adverse cardiovascular event. Aim: To investigate osteopontin serum levels in hemodialysis children and detect the association between the main arteries’ intimal medial thickness (IMT) and peak systolic velocity. Material and Methods: This case-control study included 30 children on regular hemodialysis and 30 children age and sex-matched as controls their age range from 4 to 18 years; we investigated osteopontin serum level in addition to the Doppler ultrasound assessment of intimal medial thickness and peak systolic velocity (PSV) of the main arteries in the same line with the traditional markers of the routine investigations of children on regular hemodialysis. Results: Significantly high osteopontin level in hemodialysis children than the controls was (0.85 ± 0.21 ng/ml) (0.69 ± 0.26 ng/ml), respectively (p = 0.026). A significant increase in the (IMT) of the main arteries, including the carotid and femoral arteries, in the patient’s group than the controls, was (0.51 ± 0.01 mm) (0. 69. ± 0.01 mm) (0.32 ± 0.036 mm) (0.55 ± 0.01), respectively (p = 0.001). There is a strong correlation between (OPN) with the (IMT) of carotid and femoral arteries, a significant positive correlation between (OPN) with urea, creatinine, triglyceride, PTH, ferritin, CRP, and ESR, and a negative correlation with RBCs count and carotid PSV. Conclusion: High osteopontin level is consistent with the increased IMT of the main arteries in hemodialysis children that seem to play a significant role in developing and propagating atherosclerosis in hemodialysis children, evidenced by significant association with inflammatory markers and uremic toxins.
Omission of the Bladder Flap Suggests Short Term and Long Term Benefits  [PDF]
Mona Omar, Manal A. Farahat
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.95055
Abstract: Background: Cesarean section is now the most common major surgical procedure performed on women worldwide. With the increasing numbers of cesarean sections, there is the need to utilize evidence based techniques to optimize outcomes and minimize complications. We hypothesize that omission of the bladder flap in both primary and repeat cesarean sections will be associated with shorter operating time without a significant increase in intraoperative and postoperative complications. Methods: 550 patients were enrolled in the study. They were randomly allocated in the 2 groups to evaluate the effects of cancelling the bladder dissection. Results: Significant reduction of the total operating time (p = 0.01), skin to delivery time (p = 0.02) and micro-hematuria (p = 0.01) in group with bladder omission. Long term result: Including more bladder adhesion and fibrosis in the cases with bladder dissection. Conclusions: Omission of the bladder dissection achieved short-term advantages as regards reduction of operating time, incision-delivery duration and decreased blood loss as well as long-term effects include different in the bladder adhesion.
Endometrial Injury and Sub Endometrial Doppler Study to Predict Uterine Receptivity in Women with Unexplained Infertility: A Randomized Controlled Trial  [PDF]
Manal A. Farahat, Mona Omar
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.96084
Abstract: Objectives: The aim of this work was to compare the effectiveness and safety of endometrial scratching at different times of the menstrual cycle on cumulative pregnancy rate and also to assess and clarify its relationship and effect on sub-endometrial vasculature blood flow by Doppler ultrasound, in cases of unexplained infertility attempting to conceive spontaneously (without ovulation induction). Study Design: A prospective randomized clinical control study. Patients and Methods: A total of 252 eligible participants were included in the study and randomly allocated using block randomization into three groups: Group A (n = 84): endometrial scratching was performed during the pre-ovulatory days and Group B (n = 84): endometrial scratching has been done at day 7 of the cycle. Group C (control group): includes 84 cases without endometrial scratching. The Doppler ultrasound will be done. The pulsatility index (PI) and resistance index (RI) of endometrial and sub endometrial arteries were calculated. All women were followed up to 3 months. Results: Cumulative pregnancy rate is 21.42% and 28.57% in the study groups A and B respectively which is higher than group C (control group) (4.76%) but with statistically insignificant P-value = 0.254. There is statistically significant difference in RI & PI between the studied groups and the control group on day 13 (P value < 0.001). There is statistically significant difference in PI between day 13 and day 6 for the same group in both groups (A&B) (P value < 0.003), while there is no statistically significant difference in Group C (P value = 0.156). Conclusion: Endometrial scratching is a cost-effective and easy technique which may improve clinical pregnancy rates and endometrial blood flow in women with
Transradial Approach versus Anatomical Snuff Box Distal Radial Access for Coronary Procedures  [PDF]
Saeed Shalaby Montaser, Ahmed Mohamed Emara, Shehab Adel Eletriby, Ahmed A. Tawfeek
World Journal of Cardiovascular Diseases (WJCD) , 2020, DOI: 10.4236/wjcd.2020.1010069
Abstract: Background: Radial artery catheterization is a fundamental approach that is used as a procedural access in the different catheterization laboratories so our study is a comparison between distal radial artery approach and convential traditional transradial approach to explore the fesibility and safety of coronary angiography and percutanous coronary. Aim of the Work: The purpose of our study is a comparison between the conventional transradial approach versus distal transradial approach for diagnostic and interventional coronary procedures. Materials and Methods: This is a prospective study that included 60 patients who presented to the Cardiology departments in Ahmed Maher Teaching Hospital from December 2018 until October 2019 to perform planned Transradial Coronary Angiography and/or coronary intervention. The study is divided into two groups, group (A) included 30 patients who undergone the procedure through the distal radial approach (The Anatomical Snuffbox)and group (B) included 30 patients who undergone the procedure through the traditional Transradial approach. Results: Thrombosis and hospital stay are higher significant in radial group than distal radial group and patient satisfaction is higher significant in distal radial group than traditional Transradial while there is no significant difference between both groups as regard Success and failure rate of cannulation, bleeding,
Studies on the Indo-Pacific Tridacnidae (Tridacna maxima) from the Northern Red Sea, Egypt  [PDF]
Manal S. Mekawy, Hashem A. Madkour
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.35110
Abstract: In Egypt, Tridacna Maxima are found in Gulf of Suez, Gulf of Aqaba and Red Sea. Tridacna Maxima are very important ecological species as seafood source and as a substrate for reef-associated organisms; therefore we should protect it from extinction. Recently, these species are exposed for many factors of pollution (human activities, tourism and natural resources) that affect the distribution and abundance of it. The main objective of this research is to shed some light on the origin, stratigraphic position, systematic palaeontology and geographic distribution of Tridacna Maxima. In addition to their ecologic and environmental conditions were discussed. Finally, a proposed rules for protection these species from extinction were listed. Individuals of Tridacna Maxima were collected from different sites along the red Sea coast.
Cytotoxic effects on MCF-7 breast cancer cell lines, phenol and flavonoid contents, high performance liquid chromatography (HPLC) analysis and antioxidant activity of Maerua pseudopetalosa (Gilg and Bened) De Wolf fractions
Manal A Ibrahim,Manal M Ramadan
- , 2019, DOI: 10.5897/AJPP2019.5082
Abstract:
Enhancing the Creep Resistance of Sn-9.0Zn-0.5Al Lead-Free Solder Alloy by Small Additions of Sb Element  [PDF]
E. A. Eid, Manal A. Ramadan, A. B. El Basaty
Engineering (ENG) , 2018, DOI: 10.4236/eng.2018.101003
Abstract: The creep phenomenon is considered as one of the most important deformation mechanisms under working conditions. The present study has examined the microstructure and creep properties of Sn-9.0Zn-0.5Al solder alloy after adding a small amount of Antimony (Sb). Nominal compositions of Sb additions were chosen to be 0, 0.5, 1.0, and 1.5 wt.%. The minimum strain rate was reduced for the Sb containing solder alloy. The stress exponents, n, were found to be around 3.7 for all soldiers at 130°C. The stress exponent increases as the temperature drops from 100°C to 50°C, except for the 1.0% Sb alloy, where n 5.3 - 6.1 at all the temperature range (T = 50°C, 100°C and 130°C). The results reveal that the Sb-containing solder alloys have better creep resistance with greater ductility than the Sb-free alloy due to solid solution strengthening, and intermetallic compound SnSb particle hardening.
Strategic Control of Schistosome Intermediate Host
Manal A. Hamed
Asian Journal of Epidemiology , 2010,
Abstract: Schistosomiasis is a snail-borne trematode infection of humans, domestic and wild animals in different parts of Asia, Africa, the Middle East, South America and the Carribbean. Approximately 200 million people in 74 countries are affected; 120 million of these are symptomatic and 20 million have severe disease. Elimination of schistosomiasis has been mainly accomplished by control of the snail host. As measures of snail control, cement-lining of ditches and chemical mollusciciding were most effective in many countries. But the cost of this joint program is too expensive compared with health budget in almost developing countries. Due to persisting conditions of poor health infrastructure, lack of access to clean water and poverty, re-infections in humans still poses a challenge for the long-term control of schistosomiasis. It is hoped that vaccines and better diagnosis of human will help alleviate some of these challenges. However, until these become available, alternative strategies, including blocking parasite transmission in the snail host have been considered. Several studies have been conducted in recent years to begin to understand the molecular basis of the snail-parasite interaction and to identify genes that may be involved in rendering snails resistant to infection.
NOS3 894G > T Gene Polymorphism: A Potential Risk Factor of Stroke in Bahraini Patients  [PDF]
Manal A. Fadl, Adel A. AlJishi, Safa Taha, Moiz Bakhiet
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.81009
Abstract: The endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene is responsible for the synthesis of a vasoactive endothelium-derived nitric oxide (NO). The genetic polymorphism of this gene explains, in part, why some people are prone to develop stroke than others. In this study we conducted a case control study in Bahrainis to investigate “for the first time” the relationship between NOS3 894G > T (rs1799983) and 786T > C (rs2070744) polymorphisms with the stroke predisposition in Bahraini population. Detection of NOS3 polymorphism was performed by PCR RFLP genotyping method. The level of NO among cases and controls was measured using ELISA. A total of 93 unrelated stroke patients and 86 controls were included in the study. The three types of stroke; Ischemic, hemorrhagic and transient ischemic attack were reported (91.4%, 7.5% and 1.1% respectively). No significant gender difference was observed (P = 0.74). Having previous stroke was a highly significant risk factor of the disease (P = 0.001, OR = 1.4), where as a family history of stroke was not (OR = 0.11). The analysis provides evidence that the mutant 894GT + TT genotypes of NOS3 894G > T polymorphism were positively associated with stroke predisposition and it increased the risk of
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